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Discovery and development of gliflozins : ウィキペディア英語版 | Discovery and development of gliflozins Gliflozins are a new class of drugs in the treatment of type 2 diabetes (T2D). They act by inhibiting sodium/glucose cotransporter 2 (SGLT-2), and are therefore also called SGLT-2 inhibitors. The efficacy of the drug is dependent on renal excretion and prevents glucose from going into blood circulation by promoting glucosuria. The mechanism of action is insulin independent. Three drugs have been accepted by the Food and Drug Administration (FDA) in The United States; dapagliflozin, canagliflozin and empagliflozin. Canagliflozin was the first SGLT-2 inhibitor that was approved by the FDA, it was accepted in March 2013. Dapagliflozin and empagliflozin were accepted in 2014. == Introduction ==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Discovery and development of gliflozins」の詳細全文を読む
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