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・ Discovery 20
・ Discovery Academy (Richmond Hill, Ontario)
・ Discovery Air
・ Discovery Air Defence
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・ Discovery and development of ACE inhibitors
・ Discovery and development of angiotensin receptor blockers
・ Discovery and development of antiandrogens
・ Discovery and development of beta-blockers
・ Discovery and development of beta2 agonists
・ Discovery and development of cephalosporins
・ Discovery and development of cyclooxygenase 2 inhibitors
・ Discovery and development of direct thrombin inhibitors
Discovery and development of gliflozins
・ Discovery and development of HIV-protease inhibitors
・ Discovery and development of integrase inhibitors
・ Discovery and development of matrix metalloproteinase inhibitors
・ Discovery and development of memantine and related compounds
・ Discovery and development of neuraminidase inhibitors
・ Discovery and development of non-nucleoside reverse-transcriptase inhibitors
・ Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors
・ Discovery and development of phosphodiesterase 5 inhibitors
・ Discovery and development of proton pump inhibitors
・ Discovery and development of statins
・ Discovery and development of steroidal aromatase inhibitors
・ Discovery and development of triptans
・ Discovery and development of TRPV1 antagonists
・ Discovery and development of tubulin inhibitors


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Discovery and development of gliflozins : ウィキペディア英語版
Discovery and development of gliflozins
Gliflozins are a new class of drugs in the treatment of type 2 diabetes (T2D). They act by inhibiting sodium/glucose cotransporter 2 (SGLT-2), and are therefore also called SGLT-2 inhibitors. The efficacy of the drug is dependent on renal excretion and prevents glucose from going into blood circulation by promoting glucosuria. The mechanism of action is insulin independent.
Three drugs have been accepted by the Food and Drug Administration (FDA) in The United States; dapagliflozin, canagliflozin and empagliflozin. Canagliflozin was the first SGLT-2 inhibitor that was approved by the FDA, it was accepted in March 2013. Dapagliflozin and empagliflozin were accepted in 2014.
== Introduction ==


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